Canonical and Interior Circular RNAs Function as Competing Endogenous RNAs in Psoriatic Skin

(1) Background: Understanding the function of circular RNAs (circRNAs), a class noncoding RNA, in psoriatic skin can provide important insights into complex regulation genes contributing to pathogenesis psoriasis. (2) Methods: A novel method was applied RNA-seq datasets from 93 biopsy samples comprehensively identify circRNAs all types, i.e., canonical intron-exon junctions mRNAs and interior (i-circRNAs) regions exons, introns, intergenic regions. Selected were experimentally validated by qRT-PCR Sanger sequencing. CircRNAs with abundant differential expression identified their putative as competing endogenous (ceRNAs) analyzed an integrated analysis circRNAs, microRNAs, mRNAs. (3) Results: With comprehensive search using no information splicing signals, we systematically 179 highly skin. Many these reported for first time many differentially expressed involved versus normal or uninvolved Validation based on three additional confirmed most Experimental analyses well-known circRNA CDR1as, circRNA, i-circRNA We also that may act ceRNAs regulate mRNA psoriasis-related signaling pathways (4) Conclusions: The result study suggested are skin, have distinct characteristics, contribute pathogenesis.